Crosslinking Reagents
Cayman Chemical NorcholIc AcId 50mg
A sesquiterpene lactone with diverse biological activities inhibits LPS-induced increases in nitric oxide IL-6 and TNF-a production in RAW 246.7 cells by 76.09 81.54 and 71.23 respectively at 10 M decreases cell viability GSH levels and the mitochondrial membrane potential induces apoptosis and increases ROS generation in HepG2 cells at 40 M inhibits phosphorylation and nuclear translocation of STAT3 in MDA-MB-231 cells reduces tumor growth in an MDA-MB-231 mouse xenograft model at 2.5 mg/kg
Cayman Chemical AmInoethylsPropIonIc AcId 50mg
A p300 and CBP inhibitor selectively binds to p300 and CBP over BRD4 (Kds 1 3 1 7 and 222 nM respectively) inhibits proliferation of OPM-2 cells (GI50 5 nM) induces tumor regression in MOLM-16 and OPM-2 mouse xenograft models at 20 mg/kg
Cayman Chemical 6-keto LIthocholIc AcId 50mg
A positive allosteric modulator of mGluR5 potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s 10 and 20 nM for the human and rat receptor respectively) inhibits amphetamine-induced PPI disruptions in rats at 30 mg/kg s c
Cayman Chemical PntoIc AcId 50mg
Immunogen Peptide corresponding to H2BK23Ac Host Rabbit Species Reactivity ( ) Vertebrates Cross Reactivity ( ) H2BK23Ac (-) Unmodified H2BK23 H2BK5Ac H2BK11Ac H2BK12Ac H2BK15Ac H2BK16Ac H2BK20Ac Applications ELISA ICC multiplex-based assays WB
Cayman Chemical Sulfo-SMCCsodIum salt 50mg
An analytical reference standard categorized as an arylcyclohexylamine intended for research and forensic applications
Cayman Chemical AZ 13705339 50mg
An inhibitor of FOXM1 DNA-binding activity (IC50 22.5 UM) binds to FOXM1 and is selective for inhibiting FOXM1 transcriptional activity over FOXA1 FOXA2 FOXP2 and GATA-1 transcriptional activity inhibits the growth of MCF-7 MDA-MB-231 and PEO1 cancer cells (GI50s 18 21.8 and 18.1 UM respectively)
Cayman Chemical CDDO methyl ester 50mg
Antigen phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1 expected to react with bovine canine chicken mouse non-human primates and Xenopus MEK1 Host rabbit Cross Reactivity ( ) rat MEK1 Application(s) WB MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation MEK1 is phosphorylated by MAPK on Thr292 and Thr386
Cayman Chemical GlycodehydrocholIc AcId 50mg
A mixture of short-chain and water soluble fatty acids contains acetic propionic isobutyric n-butyric 2-methylbutyric isovaleric and n-valeric acids intended for use as a reference standard for the detection of these fatty acids in various sample types by GC- or LC-MS
Cayman Chemical GlycohyodeoxycholIc AcId 50mg
A fat-soluble dietary nutrient that is essential for the synthesis of proteins important for blood-clotting bone metabolism and cell growth
Cayman Chemical 2propyl4PentenoIc AcId 50mg
An activator of RAD51 (Kd 48-107 for human RAD51) a potent enhancer of CRISPR-mediated genome editing
Cayman Chemical PerfluoroctnsulfonIc AcId 50mg
A dicarboxylic acid and metabolite of L-isoleucine and L-alloisoleucine urinary levels are increased in patients with ethylmalonic encephalopathy short-chain acyl-CoA dehydrogenase deficiency or type 2 diabetes has been found in urban and industrial aerosols of PM2.5
Cayman Chemical TIaprofenIc AcId 50mg
A coumarin with anticancer activity decreases proliferation and cell invasion induced by FBS in H1299 NSCLCs at 10 UM decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by HUVECs decreases proliferation of U937 human leukemia cells (IC50 40 UM) reduces tumor growth in a U937 mouse xenograft model at 30 mg/kg
Cayman Chemical 1 3-DIcaffeoylquInIc AcId 50mg
A flavanonol with diverse biological activities scavenges DPPH radicals (IC50 0.235 g/ml) and decreases AAPH-induced ROS generation in human erythrocytes (6 g/ml) dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells decreases tumor volume by 43.5 in a mouse xenograft model of HepG2 cells (500 mg/kg per day) binds to GABAA receptors in rat cortical membrane reparations (IC50 4.36 M) dose-dependently reduces LORR in ethanol-intoxicated rats improves cognitive deficits in a mouse model of Alzheimers disease (2 mg/kg for three months)
Cayman Chemical CryptochlorogenIc AcId 50mg
A Bcl-6 inhibitor (Ki 147 UM) selective for Bcl-6 over Kaiso HIC1 and PLZF at 50 UM cytotoxic against SU-DLH-6 SU-DLH-4 Farage OCI-LY7 OCI-LY1 and OCI-LY10 DLBCL cells (GI50s 0.024-0.936 mM) increases expression of ATR TP53 CD69 p21 and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 UM reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Cayman Chemical 3-MethylglutaconIc AcId 50mg
A reversible inhibitor of pantothenate kinase (PanK IC50s 70 92 and 25 nM for PanK1B PanK2 and PanK3 respectively) inhibits CoA biosynthesis in C3A cells (IC50 0.9 UM) sensitizes cells to ferroptosis inducers